Mano Manoharan

Mano Manoharan

Company: Alnylam Pharmaceuticals

Job title: Senior Vice President - Innovation Chemistry and Distinguished Scientist


Employing Conjugation Chemistry to Achieve Therapeutic Delivery of siRNAs to Reach Desired Tissues 2:15 pm

Modifying siRNA chemistry to better complex with conjugate delivery system Gearing conjugation chemistry for targeted siRNA delivery to elicit desired therapeutic effect Improving potency, specificity and safety of siRNAs for effective delivery to target siteRead more

day: Conference Day Two

Panel Discussion: Exploring the Strategies to Induce Extra-Hepatic Delivery & Reduce Accumulation in Liver 1:25 pm

One of the biggest challenges for delivery of RNA therapeutics has been the tendency of nanoparticles to accumulate in the liver when delivered intravenously due to the body’s natural filtration system. Changing the method of delivery (direct or subcutaneous injection) and properties such as size and surface charge has been observed to affect the accumulation…Read more

day: Conference Day One

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