Deep Learning-Based Design of Cell-Targeting Ligands Enables Cell- Specific, Functional SiRNA Delivery in Multiple Extrahepatic Tissues
Time: 12:30 pm
day: Day 2
Details:
- Receptor-mediated endocytosis drives cell tropism across RNA modalities
- Deep learning-based design of ligands targeting endocytosing receptors enables rapid in vivo testing of receptors for their capacity to mediate functional siRNA delivery
- This platform – Connexa – has led to the discovery of multiple receptors capable of mediating in vivo functional siRNA delivery in extrahepatic tissues
